The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders

CD8+ lymphocytes are adaptive immunity cells with the particular function to directly kill target cell following antigen recognition in context of MHC class I. In addition, T may release pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), a plethora other cytokines chemoattractants modulating immune inflammatory responses. A role for has been suggested aging several diseases central nervous system (CNS), including Alzheimer’s disease, Parkinson’s multiple sclerosis, amyotrophic lateral limbic encephalitis-induced temporal lobe epilepsy Susac syndrome. Here we discuss phenotypic functional alterations compartment during these conditions, highlighting similarities differences between CNS disorders. Particularly, describe pathological changes memory phenotypes emphasizing senescence exhaustion promoting neuroinflammation neurodegeneration. We also relevance trafficking molecules selectins, mucins integrins controlling extravasation into disease development. Finally, how induce tissue damage leading neurodegeneration suggest that targeting detrimental functions have therapeutic effect